Methamphetamine

Methamphetamine
INN: Metamfetamine
Clinical data
Pronunciation	/ˌmɛθæmˈfɛtəmiːn/
Tred names	Desoxyn
AHFS/Drugs.com	monograph
Leecence data	US FDA: Methamphetamine;
Pregnancy; category	US: C (Risk nae ruled oot) ; ;
Dependence; liability	Pheesical: none; Psychological: heich
Addiction; liability	Heich
Routes o; admeenistration	Medical: oral (ingestion), intravenous; Recreational: oral, intravenous, intramuscular, subcutaneous, smeuk inhalation, insufflation, rectal, vaginal
ATC code	N06BA03 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled) ; CA: Schedule I ; DE: Anlage II (Prohibitit) ; NZ: Class A ; UK: Cless A ; US: Schedule II ; UN: Psychotropic Schedule II ;
Pharmacokinetic data
Bioavailability	Oral: 70%; IV: 100%
Protein bindin	Varies widely
Metabolism	CYP2D6 and FMO3
Onset o action	Rapid
Biological hauf-life	5–30 oors
Duration o action	10–20 oors
Excretion	Primarily renal
Identifiers
	IUPAC name (RS)-N-methyl-1-phenylpropan-2-amine;
Synonyms	N-methylamphetamine, N,α-dimethylphenethylamine, desoxyephedrine
CAS Nummer	537-46-2 ;
PubChem CID	1206;
IUPHAR/BPS	4803;
DrugBank	DB01577 ;
ChemSpider	1169 ;
UNII	44RAL3456C;
KEGG	D08187 ;
ChEBI	CHEBI:6809 ;
ChEMBL	CHEMBL1201201 ;
PDB ligand	B40 (PDBe, RCSB PDB);
ECHA InfoCard	100.007.882
Chemical and physical data
Formula	C10H15N
Molar mass	149.24 g·mol−1
3D model (Jmol)	Interactive eemage;
Chirality	Racemic mixtur
Meltin pynt	3 °C (37 °F) (predicted)
Bylin pynt	212 °C (414 °F) at 760 mmHg
	SMILES N(C(Cc1ccccc1)C)C;
	InChI InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3 ; Key:MYWUZJCMWCOHBA-UHFFFAOYSA-N ;
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Methamphetamine (contractit frae N-methylamphetamine) is a strang central nervish seestem (CNS) stimulant that is mainly uised as a recreational drog an less commonly as a treatment for attention deficit hyperactivity disorder an obesity.

References

↑ United States Congress Senate Committee on the Judiciary Subcommittee to Investigate Juvenile Delinquincy (1 Januar 1972). Amphetamine legislation 1971: Hearings, Ninety-second Congress, first session, pursuant to S. Res. 32, section 12, investigation of juvenile delinquency in the United States (PDF). U.S. Govt. Print. Off. p. 161. Archived frae the original (PDF) on 6 Mey 2010. Retrieved 1 Januar 2016. We made a decision in January of 1969 to cease the manufacture of injectable methamphetamines.
↑ ^a ^b Rau T, Ziemniak J, Poulsen D (2015). "The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury". Prog. Neuropsychopharmacol. Biol. Psychiatry. 64: 231–6. doi:10.1016/j.pnpbp.2015.02.013. PMID 25724762. In humans, the oral bioavailability of methamphetamine is approximately 70% but increases to 100% following intravenous (IV) delivery (Ares-Santos et al., 2013).
↑ "Toxicity". Methamphetamine. PubChem Compound. National Center for Biotechnology Information. Retrieved 31 December 2013.
↑ "Adderall XR Prescribing Information" (PDF). United States Food and Drug Administration. December 2013. pp. 12–13. Retrieved 30 December 2013.
↑ Krueger SK, Williams DE (Juin 2005). "Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism". Pharmacol. Ther. 106 (3): 357–387. doi:10.1016/j.pharmthera.2005.01.001. PMC 1828602. PMID 15922018.
↑ ^a ^b Riviello, Ralph J. (2010). Manual of forensic emergency medicine : a guide for clinicians. Sudbury, Mass.: Jones and Bartlett Publishers. p. 41. ISBN 9780763744625.
↑ Schep LJ, Slaughter RJ, Beasley DM (August 2010). "The clinical toxicology of metamfetamine". Clinical Toxicology (Philadelphia, Pa.). 48 (7): 675–694. doi:10.3109/15563650.2010.516752. ISSN 1556-3650. PMID 20849327.
↑ "Properties: Predicted – EP|Suite". Methmphetamine. Chemspider. Retrieved 3 Januar 2013.
↑ "Chemical and Physical Properties". Methamphetamine. PubChem Compound. National Center for Biotechnology Information. Retrieved 31 December 2013.

[RxMethIV-1] United States Congress Senate Committee on the Judiciary Subcommittee to Investigate Juvenile Delinquincy (1 Januar 1972). Amphetamine legislation 1971: Hearings, Ninety-second Congress, first session, pursuant to S. Res. 32, section 12, investigation of juvenile delinquency in the United States (PDF). U.S. Govt. Print. Off. p. 161. Archived frae the original (PDF) on 6 Mey 2010. Retrieved 1 Januar 2016. We made a decision in January of 1969 to cease the manufacture of injectable methamphetamines.

[Bioavailability-2] Rau T, Ziemniak J, Poulsen D (2015). "The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury". Prog. Neuropsychopharmacol. Biol. Psychiatry. 64: 231–6. doi:10.1016/j.pnpbp.2015.02.013. PMID 25724762. In humans, the oral bioavailability of methamphetamine is approximately 70% but increases to 100% following intravenous (IV) delivery (Ares-Santos et al., 2013).

[Pubchem1-3] "Toxicity". Methamphetamine. PubChem Compound. National Center for Biotechnology Information. Retrieved 31 December 2013.

[FDA_Pharmacokinetics-4] "Adderall XR Prescribing Information" (PDF). United States Food and Drug Administration. December 2013. pp. 12–13. Retrieved 30 December 2013.

[FMO-5] Krueger SK, Williams DE (Juin 2005). "Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism". Pharmacol. Ther. 106 (3): 357–387. doi:10.1016/j.pharmthera.2005.01.001. PMC 1828602. PMID 15922018.

[Ri2010-6] Riviello, Ralph J. (2010). Manual of forensic emergency medicine : a guide for clinicians. Sudbury, Mass.: Jones and Bartlett Publishers. p. 41. ISBN 9780763744625.

[Schep-7] Schep LJ, Slaughter RJ, Beasley DM (August 2010). "The clinical toxicology of metamfetamine". Clinical Toxicology (Philadelphia, Pa.). 48 (7): 675–694. doi:10.3109/15563650.2010.516752. ISSN 1556-3650. PMID 20849327.

[Chemspider-8] "Properties: Predicted – EP|Suite". Methmphetamine. Chemspider. Retrieved 3 Januar 2013.

[Pubchem2-9] "Chemical and Physical Properties". Methamphetamine. PubChem Compound. National Center for Biotechnology Information. Retrieved 31 December 2013.

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