Ibuprofen

Ibuprofen
Clinical data
Tred names	Advil, Brufen, Motrin, Nurofen, etc.
AHFS/Drugs.com	monograph
MedlinePlus	a682159
Leecence data	US FDA: Ibuprofen;
Pregnancy; category	AU: C ; US: D (Evidence o risk) ; ;
Routes o; admeenistration	Oral, rectal, topical, an intravenous
ATC code	C01EB16 (WHO) G02CC01 (WHO) M01AE01 (WHO) M02AA13 (WHO);
Legal status
Legal status	AU: Unscheduled ; CA: OTC ; UK: General sales leet (GSL, OTC) ; US: OTC ;
Pharmacokinetic data
Bioavailability	49–73%
Protein bindin	99%
Metabolism	Hepatic (CYP2C9)
Biological hauf-life	1.8–2 h
Excretion	Renal
Identifiers
	IUPAC name (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid;
CAS Nummer	15687-27-1 ;
PubChem CID	3672;
IUPHAR/BPS	2713;
DrugBank	DB01050 ;
ChemSpider	3544 ;
UNII	WK2XYI10QM;
KEGG	D00126 ;
ChEBI	CHEBI:5855 ;
ChEMBL	CHEMBL521 ;
ECHA InfoCard	100.036.152
Chemical and physical data
Formula	C13H18O2
Molar mass	206.29 g/mol
3D model (Jmol)	Interactive eemage;
Density	1,03 gr/ml g/cm3
Meltin pynt	76 °C (169 °F)
	SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)O;
	InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) ; Key:HEFNNWSXXWATRW-UHFFFAOYSA-N ;
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Ibuprofen (INN) (/ˈaɪbjuːproʊfɛn/ or /aɪbjuːˈproʊfən/ EYE-bew-PROH-fən; from iso-butyl-propanoic-phenolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction,^[1] and against swelling.

Ibuprofen has an antiplatelet effect, though relatively mild and somewhat short-lived compared with aspirin or prescription antiplatelet drugs. In general, ibuprofen has a vasodilation effect^[2]. Ibuprofen is a 'core' medicine in the World Health Organization's Model List of Essential Medicines necessary that meet the minimum medical needs of a basic healthcare system.^[3]^[4]^[5]^[6]

Ibuprofen was derived from propanoic acid by the research firm of Boots Group during the 1960s^[7] and patented 1961. Orginal market as Brufen, ibuprofen is available under a variety of popular trademarks, including Motrin, Nurofen, Advil, Nuprin, and many others.^[8] Generic formulations are available as well.

References eedit

↑ Van Esch, A; Van Steensel-Moll, HA; Steyerberg, EW; Offringa, M; Habbema, JD; Derksen-Lubsen, G (Juin 1995). "Antipyretic efficacy of ibuprofen and acetaminophen in children with febrile seizures". Archives of pediatrics & adolescent medicine. 149 (6): 632–7. PMID 7767417.
↑ Apstein, CS; Vogel, WM (Januar 1982). "Coronary arterial vasodilator effect of ibuprofen". The Journal of pharmacology and experimental therapeutics. 220 (1): 167–71. PMID 7053413.
↑ WHO Model List of Essential Medicines (PDF) (16th ed.). World Health Organization (WHO). Mairch 2009. Retrieved 30 Mairch 2011.
↑ WHO Model List of Essential Medicines for Children (PDF) (2nd ed.). World Health Organization (WHO). Mairch 2010. Retrieved 30 Mairch 2011.
↑ Stuart MC; Kouimtzi M; Hill SR, eds. (2009). WHO Model Formulary 2008 (PDF) (2nd ed.). World Health Organization (WHO). ISBN 978-92-4-154765-9. Retrieved 30 Mairch 2011.
↑ WHO Model Formulary for Children 2010 (PDF) (2nd ed.). World Health Organization (WHO). 2010. ISBN 978-92-4-159932-0. Retrieved 30 Mairch 2011.
↑ Adams, SS (Apryle 1992). "The propionic acids: a personal perspective". Journal of clinical pharmacology. 32 (4): 317–23. PMID 1569234.
↑ "PubMed Health - Ibuprofen". U.S. National Library of Medicine. 1 October 2010. Retrieved 20 Januar 2011.

External links eedit

[1] Van Esch, A; Van Steensel-Moll, HA; Steyerberg, EW; Offringa, M; Habbema, JD; Derksen-Lubsen, G (Juin 1995). "Antipyretic efficacy of ibuprofen and acetaminophen in children with febrile seizures". Archives of pediatrics & adolescent medicine. 149 (6): 632–7. PMID 7767417.

[protection-2] Apstein, CS; Vogel, WM (Januar 1982). "Coronary arterial vasodilator effect of ibuprofen". The Journal of pharmacology and experimental therapeutics. 220 (1): 167–71. PMID 7053413.

[essentialWHO-3] WHO Model List of Essential Medicines (PDF) (16th ed.). World Health Organization (WHO). Mairch 2009. Retrieved 30 Mairch 2011.

[WHOchild-4] WHO Model List of Essential Medicines for Children (PDF) (2nd ed.). World Health Organization (WHO). Mairch 2010. Retrieved 30 Mairch 2011.

[WHOmod-5] Stuart MC; Kouimtzi M; Hill SR, eds. (2009). WHO Model Formulary 2008 (PDF) (2nd ed.). World Health Organization (WHO). ISBN 978-92-4-154765-9. Retrieved 30 Mairch 2011.

[WHOmodchild-6] WHO Model Formulary for Children 2010 (PDF) (2nd ed.). World Health Organization (WHO). 2010. ISBN 978-92-4-159932-0. Retrieved 30 Mairch 2011.

[pmid1569234-7] Adams, SS (Apryle 1992). "The propionic acids: a personal perspective". Journal of clinical pharmacology. 32 (4): 317–23. PMID 1569234.

[knownbrands-8] "PubMed Health - Ibuprofen". U.S. National Library of Medicine. 1 October 2010. Retrieved 20 Januar 2011.

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