Serotonin

Serotonin
Names
	IUPAC names 5-Hydroxytryptamine or; 3-(2-aminoethyl)-1H-indol-5-ol
	Ither names 5-Hydroxytryptamine, 5-HT, Enteramine; Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyindole, Thrombotonin
Identifiers
CAS Nummer	50-67-9 ;
3D model (JSmol)	Interactive eemage;
ChEBI	CHEBI:28790 ;
ChEMBL	ChEMBL39 ;
ChemSpider	5013 ;
IUPHAR/BPS	5;
KEGG	C00780 ;
MeSH	Serotonin
PubChem CID	5202;
UNII	333DO1RDJY ;
	InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 Key: QZAYGJVTTNCVMB-UHFFFAOYSA-N ; InChI=1/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 Key: QZAYGJVTTNCVMB-UHFFFAOYAX;
	SMILES c1cc2c(cc1O)c(c[nH]2)CCN;
Properties
Chemical formula	C10H12N2O
Molar mass	176.215 g/mol
Appearance	White pouder
Meltin pynt	121–122 °C (ligroin)
Bylin pynt	416 ± 30 °C (at 760 Torr)
Solubility in watter	slichtly soluble
Acidity (pKa)	10.16 in watter at 23.5 °C
Dipole moment	2.98 D
Hazards
	Lethal dose or concentration (LD, LC):
LD50 (Median dose)	750 mg/kg (subcutaneous, rat), 4500 mg/kg (intraperitoneal, rat), 60 mg/kg (oral, rat)
	Except whaur itherwise notit, data are gien for materials in thair staundart state (at 25 °C [77 °F], 100 kPa).
	verify (whit is ?)
	Infobox references

Serotonin /ˌsɛrəˈtoʊnᵻn/ or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Biochemically derived frae tryptophan, serotonin is primarily foond in the gastrointestinal (GI) tract, platelets, an the central nervous seestem (CNS) o animals, includin humans.

ReferencesEedit

↑ Pietra, S.;Farmaco, Edizione Scientifica 1958, Vol. 13, pp. 75–9.
↑ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994–2011 ACD/Labs)
↑ Mazák, K.; Dóczy, V.; Kökösi, J.; Noszál, B. (2009). "Proton Speciation and Microspeciation of Serotonin and 5-Hydroxytryptophan". Chemistry & Biodiversity. 6 (4): 578–90. doi:10.1002/cbdv.200800087. PMID 19353542.CS1 maint: multiple names: authors leet (link)
↑ Erspamer, Vittorio (1952). Ricerca Scientifica. 22: 694–702. Missing or empty |title= (help)
↑ Tammisto, Tapani (1968). Annales Medicinae Experimentalis et Biologiea Fenniae. 46 (3, Pt. 2): 382–4. Missing or empty |title= (help)

Names



IUPAC names 5-Hydroxytryptamine or 3-(2-aminoethyl)-1H-indol-5-ol
Ither names 5-Hydroxytryptamine, 5-HT, Enteramine; Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyindole, Thrombotonin
Identifiers
CAS Nummer	50-67-9^Y
3D model (JSmol)	Interactive eemage
ChEBI	CHEBI:28790^Y
ChEMBL	ChEMBL39^Y
ChemSpider	5013^Y
IUPHAR/BPS	5
KEGG	C00780^Y
MeSH	Serotonin
PubChem CID	5202
UNII	333DO1RDJY^Y
InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2^Y Key: QZAYGJVTTNCVMB-UHFFFAOYSA-N^Y InChI=1/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 Key: QZAYGJVTTNCVMB-UHFFFAOYAX
SMILES c1cc2c(cc1O)c(c[nH]2)CCN
Properties
Chemical formula	C₁₀H₁₂N₂O
Molar mass	176.215 g/mol
Appearance	White pouder
Meltin pynt	121–122 °C (ligroin) ^[1]
Bylin pynt	416 ± 30 °C (at 760 Torr) ^[2]
Solubility in watter	slichtly soluble
Acidity (pK_a)	10.16 in watter at 23.5 °C ^[3]
Dipole moment	2.98 D
Hazards
Lethal dose or concentration (LD, LC):
LD₅₀ (Median dose)	750 mg/kg (subcutaneous, rat),^[4] 4500 mg/kg (intraperitoneal, rat),^[5] 60 mg/kg (oral, rat)
Except whaur itherwise notit, data are gien for materials in thair staundart state (at 25 °C [77 °F], 100 kPa).
Y verify (whit is ^YN ?)
Infobox references