Serotonin
Serotonin /ˌsɛrəˈtoʊnᵻn/ or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Biochemically derived frae tryptophan, serotonin is primarily foond in the gastrointestinal (GI) tract, platelets, an the central nervous seestem (CNS) o animals, includin humans.
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Names | |
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IUPAC names
5-Hydroxytryptamine or
3-(2-aminoethyl)-1H-indol-5-ol | |
Ither names
5-Hydroxytryptamine, 5-HT, Enteramine; Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyindole, Thrombotonin
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.000.054 |
KEGG | |
MeSH | Serotonin |
PubChem CID
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UNII | |
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Properties | |
C10H12N2O | |
Molar mass | 176.215 g/mol |
Appearance | White pouder |
Meltin pynt | 121–122 °C (ligroin) [1] |
Bylin pynt | 416 ± 30 °C (at 760 Torr) [2] |
slichtly soluble | |
Acidity (pKa) | 10.16 in watter at 23.5 °C [3] |
2.98 D | |
Hazards | |
Lethal dose or concentration (LD, LC): | |
LD50 (Median dose)
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750 mg/kg (subcutaneous, rat),[4] 4500 mg/kg (intraperitoneal, rat),[5] 60 mg/kg (oral, rat) |
Except whaur itherwise notit, data are gien for materials in thair staundart state (at 25 °C [77 °F], 100 kPa). | |
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Infobox references | |
ReferencesEedit
- ↑ Pietra, S.;Farmaco, Edizione Scientifica 1958, Vol. 13, pp. 75–9.
- ↑ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994–2011 ACD/Labs)
- ↑ Mazák, K.; Dóczy, V.; Kökösi, J.; Noszál, B. (2009). "Proton Speciation and Microspeciation of Serotonin and 5-Hydroxytryptophan". Chemistry & Biodiversity. 6 (4): 578–90. doi:10.1002/cbdv.200800087. PMID 19353542.
- ↑ Erspamer, Vittorio (1952). Ricerca Scientifica. 22: 694–702. Missing or empty
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(help) - ↑ Tammisto, Tapani (1968). Annales Medicinae Experimentalis et Biologiea Fenniae. 46 (3, Pt. 2): 382–4. Missing or empty
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(help)